Saint Louis University's Interdisciplinary Science and Engineering (ISE) building features scale-up classrooms, and flexible lab spaces. Opened in summer 2020, the 90,000-square-foot, building is a place where students and faculty learn, collaborate and experiment. A 3-story atrium experience in the main lobby combines moiré STEM@SLU letters measuring 3´-2´ x 21´ and a large content changing screen and 10 smaller screens. Other wall graphics juxtapose reflective, matte, metallic, and translucent finishes reflecting the rhythm and pattern of life, and science of human interactions. The materials and surfaces demonstrate the illusion of depth: shiny versus matte, glowing and iridescent—all properties which speak to science, technology and innovation. The moniker STEM@SLU brings attention to the interdisciplinary way of teaching and learning.